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Randomized trials for the treatment of burning mouth syndrome: an evidence‐based review of the literature
Author(s) -
de Moraes Maiara,
do Amaral Bezerra Bruna Aguiar,
da Rocha Neto Pedro Carlos,
de Oliveira Soares Ana Clara Azevedo,
Pinto Leão Pereira,
de Lisboa Lopes Costa Antonio
Publication year - 2012
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2011.01100.x
Subject(s) - medicine , burning mouth syndrome , randomized controlled trial , burning sensation , clonazepam , psychological intervention , physical therapy , sample size determination , intensive care medicine , dermatology , psychiatry , statistics , mathematics
J Oral Pathol Med (2012) 41 : 281–287 Burning mouth syndrome (BMS) is defined as a chronic pain condition, characterized symptomatically by a generalized or localized burning sensation in the oral cavity. Various drugs have been used in attempting to treat BMS, but there is insufficient evidence to show the effect of any effective treatment. The aim of this review was to assess the effectiveness of therapies for BMS. Randomized controlled trials (RCTs) enrolling patients with a diagnosis of BMS were identified by searching Pubmed and Scoppus databases. The methodological quality of included studies was assessed on the basis of the method of allocation concealment, blindness of the study, loss of participants, size sample, and outcome concealment. A total of 12 relevant articles were analyzed. Therapies that used capsaicin, alpha‐lipoic acid (ALA), and clonazepam were those that showed more reduction in symptoms of BMS. However, many studies of therapeutic interventions in BMS lack consistency in their results, because they use in their methodology, sample and a relatively short time of therapy and often do not provide a follow‐up of patients treated. Thus, future studies are required to establish the treatment for patients suffering from this chronic and painful syndrome.