Premium
Immunohistochemical assessment of CD1a‐positive Langerhans cells and their relationship with E‐cadherin in minor salivary gland tumors
Author(s) -
Dultra Fátima Karoline Araújo Alves,
Barros Adna Conceição,
SchaerBarbosa Helenemarie,
Figueiredo Andréia Leal,
Gurgel Clarissa Araújo Silva,
Ramos Eduardo Antônio Gonçalves,
da Silva Carvalho Ana Maria,
dos Santos Jean Nunes
Publication year - 2012
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2011.01052.x
Subject(s) - salivary gland , immunohistochemistry , minor salivary glands , pathology , cadherin , medicine , biology , cell , genetics
J Oral Pathol Med (2012) 41 : 47–53 Objective: The aim of this study was to investigate the presence of CD1a‐positive Langerhans cells and their relationship with E‐cadherin in minor salivary gland tumors. Methods: Twenty‐seven minor salivary gland tumors were investigated using immunohistochemistry for CD1a and E‐cadherin. Results: A significant difference regarding the mean density of CD1a‐positive Langerhans cells was observed between pleomorphic adenomas and malignant tumors studied ( P = 0.001). No CD1a‐positive cells were detected in most cases ( n = 5) of cystic adenoid carcinomas. CD1a‐positive cells were detected in one mucoepidermoid carcinoma case, and six low‐grade polymorphous adenocarcinomas cases. Comparison of the mean density of CD1a‐positive cells between the three malignant tumors showed no significant difference ( P = 0.127). No significant difference was observed in the presence of E‐cadherin between tumors ( P = 0.73), but it was detected in 24 cases. Conclusions: The lack of CD1a‐positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E‐cadherin mediates cell adhesion in these tumors although we did not demonstrate significance.