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Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma
Author(s) -
Costa Nádia Lago,
Gonçalves Andréia Souza,
SouzaLima Nathália Caroline,
JaimePaiva Luís Gustavo,
JunqueiraKipnis Ana Paula,
Silva Tarcília Aparecida,
Mendonça Elismauro Francisco,
Batista Aline Carvalho
Publication year - 2011
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2011.01014.x
Subject(s) - perforin , oral mucosa , dysplasia , granzyme b , granzyme , cd8 , carcinoma , cytotoxic t cell , immunohistochemistry , medicine , pathology , leukoplakia , oral lichen planus , biology , cancer , cancer research , immunology , immune system , biochemistry , in vitro
J Oral Pathol Med (2011) 40 : 380–384 Background: Perforin and granzyme B (GB) are the main constituents of cytotoxic T‐lymphocyte granules, and they have important roles in preventing the initiation and progression of cancer. Methods: The aim of this study was to compare the expression of CD8 + /perforin + double‐staining and GB + cells, by immunohistochemistry, in primary oral cavity squamous cell carcinoma (OCSCC), lip squamous cell carcinoma (LSCC), non‐dysplastic leukoplakia (LK), dysplastic LK, actinic cheilitis (AC), oral lichen planus (LP) and normal oral mucosa. Results: Our results showed a higher expression of CD8 + /perforin + and GB + cells in LSCC when compared with the samples of OCSCC, non‐dysplastic and dysplastic LK, AC, oral LP and normal oral mucosa. In addition, increased CD8 + /perforin + and GB + cell numbers were observed in all pre‐malignant lesions (non‐dysplastic LK, dysplastic LK, AC) when compared with the control. Conclusions: Perforin and GB proteins may contribute to antitumoural immunity, leading to the direct killing of tumour cells; however, it seems to occur more effectively in LSCC than OCSCC.