Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma | Zendy

Costa Nádia Lago | Zendy; Gonçalves Andréia Souza | Zendy; SouzaLima Nathália Caroline | Zendy; JaimePaiva Luís Gustavo | Zendy; JunqueiraKipnis Ana Paula | Zendy; Silva Tarcília Aparecida | Zendy; Mendonça Elismauro Francisco | Zendy; Batista Aline Carvalho | Zendy

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Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma

Author(s) -

Costa Nádia Lago,

Gonçalves Andréia Souza,

SouzaLima Nathália Caroline,

JaimePaiva Luís Gustavo,

JunqueiraKipnis Ana Paula,

Silva Tarcília Aparecida,

Mendonça Elismauro Francisco,

Batista Aline Carvalho

Publication year - 2011

Publication title -

journal of oral pathology and medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.887

H-Index - 83

eISSN - 1600-0714

pISSN - 0904-2512

DOI - 10.1111/j.1600-0714.2011.01014.x

Subject(s) - perforin , oral mucosa , dysplasia , granzyme b , granzyme , cd8 , carcinoma , cytotoxic t cell , immunohistochemistry , medicine , pathology , leukoplakia , oral lichen planus , biology , cancer , cancer research , immunology , immune system , biochemistry , in vitro

J Oral Pathol Med (2011) 40 : 380–384 Background: Perforin and granzyme B (GB) are the main constituents of cytotoxic T‐lymphocyte granules, and they have important roles in preventing the initiation and progression of cancer. Methods: The aim of this study was to compare the expression of CD8 + /perforin + double‐staining and GB + cells, by immunohistochemistry, in primary oral cavity squamous cell carcinoma (OCSCC), lip squamous cell carcinoma (LSCC), non‐dysplastic leukoplakia (LK), dysplastic LK, actinic cheilitis (AC), oral lichen planus (LP) and normal oral mucosa. Results: Our results showed a higher expression of CD8 + /perforin + and GB + cells in LSCC when compared with the samples of OCSCC, non‐dysplastic and dysplastic LK, AC, oral LP and normal oral mucosa. In addition, increased CD8 + /perforin + and GB + cell numbers were observed in all pre‐malignant lesions (non‐dysplastic LK, dysplastic LK, AC) when compared with the control. Conclusions: Perforin and GB proteins may contribute to antitumoural immunity, leading to the direct killing of tumour cells; however, it seems to occur more effectively in LSCC than OCSCC.

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