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Evidence for a possible anatomical subsite–mediated effect of tobacco in oral potentially malignant disorders and carcinoma
Author(s) -
Pentenero Monica,
Giaretti Walter,
Navone Roberto,
Rostan Isabella,
Gassino Lavinia,
Broccoletti Roberto,
Arduino Paolo Giacomo,
Malacarne Davide,
Gandolfo Sergio
Publication year - 2011
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2010.00984.x
Subject(s) - medicine , buccal mucosa , tongue , oral mucosa , buccal administration , odds ratio , oral submucous fibrosis , pathology , carcinoma , oral cavity , dermatology , gastroenterology , dentistry
J Oral Pathol Med (2011) 40 : 214–217 Purpose: To test the hypothesis that cigarette smokers develop oral potentially malignant disorders or carcinomas in preferential anatomical subsites. Methods: The association of smoking habit with the presence of oral lesions in specific anatomical subsites was assessed in 123 patients using the odds ratio analysis. Results: When compared to all the other subsites, the relative frequency of smokers with lesions was higher in the buccal mucosa and in the floor of the mouth (FOM) ( P = 0.002 and P = 0.005), while it was lower in the tongue ( P < 0.0005). Smokers were about 7 years younger than non‐smokers ( P = 0.008). Conclusions: The association of smoking and age suggests that smoking may contribute to generate a field of injury that leads to lesions in shorter periods than other causes. The stronger relationship of smoking with lesions in the buccal mucosa and FOM than in the tongue suggests that tissue characteristics mediate the effects of tobacco.