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Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior
Author(s) -
de Faria Paulo Rogério,
Lima Roberto Araújo,
Dias Fernando Luiz,
de Faria Paulo Antônio Silvestre,
Eisenberg Ana Lucia Amaral,
do Nascimento Souza Kelen Christine,
Cardoso Sergio Vitorino,
Loyola Adriano Mota
Publication year - 2011
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2010.00980.x
Subject(s) - thymidine phosphorylase , salivary gland , vascular endothelial growth factor , thymidine , pathology , angiogenesis , vascular endothelial growth factor c , biology , vascular endothelial growth factor a , cancer research , medicine , endocrinology , vegf receptors , cancer , dna , biochemistry
J Oral Pathol Med (2010) 40 : 456–459 Background: Metastasis of salivary gland tumors has a negative impact on survival. Angiogenesis and its factors are potential markers for predicting metastasis in different malignant tumors, but this is not the case for salivary gland tumors. Methods: Salivary gland tumors of distinct biologic behavior were analyzed according to the semiquantitative immunoexpression of vascular endothelial growth factor (VEGF) and thymidine phosphorylase (TP). Results: Vascular endothelial growth factor expression was predominantly weak in benign tumors. Weak TP expression was observed in 100% cases of benign tumors and in 74.3% of primary malignant tumors. High VEGF and TP expression levels were significantly associated with primary malignant tumors but not with primary non‐metastasizing and primary metastasizing malignant tumors or with subtypes of malignant tumors. Conclusions: Vascular endothelial growth factor and TP expression levels discriminate benign and malignant tumors but cannot predict metastasis from non‐metastasizing tumors.