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Osteopontin expression in salivary gland carcinomas
Author(s) -
Bjørndal Kristine,
Larsen Stine R.,
Godballe Christian,
Krogdahl Annelise
Publication year - 2011
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2010.00964.x
Subject(s) - osteopontin , salivary gland , acinic cell carcinoma , mucoepidermoid carcinoma , pathology , adenoid cystic carcinoma , salivary gland cancer , medicine , carcinoma , cancer , adenoid , immunostaining , immunohistochemistry , oncology
J Oral Pathol Med (2010) 40 : 451–455 Background: In several cancer types, osteopontin (OPN) expression has been correlated with tumor progression and prognosis. Two earlier studies have examined OPN expression in salivary gland carcinomas with contradictory results. Methods: One hundred and seventy‐five patients with a primary salivary gland carcinoma diagnosed from January 1, 1990 to December 31, 2005 were identified in the local pathology register, Odense University Hospital. Criteria as documented by Allred et al. were used to assess OPN immunostaining that was performed on surgical specimens. Results: Osteopontin was expressed in all salivary gland carcinomas. Adenoid cystic carcinomas had the highest mean sum score (7.3) and a significantly higher proportion of carcinomas with high OPN sum score than both mucoepidermoid carcinoma and acinic cell carcinoma. Correlation of OPN expression with known prognostic factors in salivary gland carcinomas was insignificant. Conclusions: Salivary gland carcinomas express OPN. The expression does not correlate with known prognostic factors.