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Angiogenin expression in head and neck basaloid and conventional squamous cell carcinoma: a site‐ and stage‐matched comparison
Author(s) -
Marioni Gino,
Staffieri Alberto,
Savastano Marina,
Marino Filippo,
Giacomelli Luciano,
Lionello Marco,
Casotto Filippo,
de Filippis Cosimo,
Blandamura Stella
Publication year - 2011
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2010.00942.x
Subject(s) - angiogenin , angiogenesis , head and neck squamous cell carcinoma , medicine , carcinoma , pathology , stage (stratigraphy) , cell , basal cell , cancer research , oncology , biology , head and neck cancer , cancer , paleontology , genetics
J Oral Pathol Med (2011) 40 : 55–60 Background: Basaloid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma (SCC). Angiogenin (ANG), a member of the ribonuclease super‐family, is essential to tumor angiogenesis, but has also been implicated in tumor consolidation and proliferation. Methods: ANG expression was first investigated in 12 head and neck basaloid squamous cell carcinomas (HNBSCCs) and compared with a control group of 24 site‐ and stage‐matched conventional SCCs to establish whether the supposedly more aggressive biological behavior of HNBSCCs might be ANG‐related. Results: No significant differences were found between HNBSCCs, and SCCs in terms of recurrence, disease‐free survival (DFS), or overall survival rates. In HNBSCC, we identified a trend toward a significant inverse correlation between endothelial ANG expression and DFS (statistical trend, P = 0.08). Endothelial ANG expression did not differ significantly in HNBSCCs and SCCs. A high ANG expression in carcinoma cells was directly associated with pT in both the HNBSCC ( P = 0.04) and the SCC (statistical trend, P = 0.07) groups. ANG expression in carcinoma cells was significantly lower in HNBSCCs than in SCCs ( P = 0.005). Conclusions: All the biological mechanisms investigated to date, including ANG‐mediated angiogenesis or cell proliferation, have failed to confirm that HNBSCCs have a more aggressive behavior than matched SCC.