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Overexpression of GLUT‐1 in the invasion front is associated with depth of oral squamous cell carcinoma and prognosis
Author(s) -
Ohba Shinichi,
Fujii Hiroaki,
Ito Shin,
Fujimaki Mitsuhisa,
Matsumoto Fumihiko,
Furukawa Masayuki,
Yokoyama Junkichi,
Kusunoki Takeshi,
Ikeda Katsuhisa,
Hino Okio
Publication year - 2010
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2009.00814.x
Subject(s) - immunostaining , medicine , metastasis , pathology , carcinoma , cancer , lymph node , basal cell , cell , oncology , immunohistochemistry , biology , genetics
J Oral Pathol Med (2010) 39 : 74–78 Object: Malignant cells show increased uptake, which is considered to be facilitated by glucose transporters (GLUTs). Increased GLUT‐1 expression has been reported in many human cancers. We hypothesized that a oral squamous cell carcinoma, characterized by high frequency of lymph node metastasis, distant metastasis or local recurrences, was associated with GLUT‐1 overexpression in invasion front. Methods: GLUT‐1 immunostaining in invasion front was studied on 24 oral squamous cell carcinomas, and revealed the correlation with the clinical characteristics. Result: The analysis showed that all oral squamous cell carcinoma patients and GLUT‐1 expression correlated the depth of the tumors ( P = 0.023 < 0.05). Furthermore the survival of patients who had overexpression of invasion front was significant shorter than that of patients with GLUT‐1 weakly positive ( P = 0.046 < 0.05). No significant association was noted between GLUT‐1 immunostaining and either age, gender, subsites, tumor size, or lymph node status. Conclusion: The present study shows that GLUT‐1 served as a marker indicating that tumors with deep invasion tended to result in a worse prognosis in patients due to either lymph node metastasis, a recurrence of the primary lesion or distant metastasis.