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The efficacy of topical hyaluronic acid in the management of oral lichen planus
Author(s) -
Nolan A.,
Badminton J.,
Maguire J.,
Seymour R. A.
Publication year - 2009
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2008.00739.x
Subject(s) - oral lichen planus , medicine , placebo , hyaluronic acid , randomized controlled trial , dermatology , clinical trial , clinical efficacy , significant difference , oral administration , pathology , alternative medicine , anatomy
Background: The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) gel preparation (0.2%) in the management of oral lichen planus (OLP). Methods: A total of 124 patients with erosive OLP participated in a randomized, placebo‐controlled, double‐blind trial to evaluate the efficacy of a topical HA preparation. Outcome measures included soreness relief following immediate application, oral function and size of erosive/ulcerative area. Patients were medicated for 28 days and completed a log diary recording oral function and soreness scores. Results: Application of topical HA produced a significant reduction ( P < 0.05) in soreness scores when compared with placebo for up to 4 h post‐application. There was no difference between treatment groups ( P > 0.05) with respect to oral function. Patients treated with 0.2% HA showed a significant reduction ( P < 0.05) in the size of the erosive/ulcerated area after 28 days of treatment when compared with baseline. There was no significant difference in changes in ulcerative areas between treatment groups. Conclusions: Topical HA (0.2%) does appear to be of some benefit in the management of erosive lichen planus providing efficacy for up to 4 h after administration. Very frequent applications should be considered to obtain a more significant clinical benefit. Topical HA gel may be a useful addition to the treatment option for OLP.