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Additional use of DNA‐image cytometry improves the assessment of resection margins
Author(s) -
Handschel Jörg,
Öz Döne,
Pomjanski Natalia,
Depprich Rita,
Ommerborn Michelle A.,
Braunstein Stefan,
Kübler Norbert R.,
Meyer Ulrich,
Böcking Alfred
Publication year - 2007
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2007.00564.x
Subject(s) - cytometry , flow cytometry , medicine , carcinoma , pathology , immunology
Background: Despite the histopathologic findings of tumor‐free margins, patients with oral squamous cell carcinoma (SCC) often suffer from local tumor relapse. The purpose of this study was to determine the prognostic value of DNA‐image cytometry in the assessment of resection margins. Methods: DNA‐image cytometry was performed in 40 SCC patients with histologically tumor‐free resection margins. The follow‐up period since the tumor resection was at least 3 years. Results: Twenty patients showed a locoregional relapse of the SCC. Fourteen of these patients had aneuploid cells in DNA‐image cytometry. Two patients who were relapse‐free revealed aneuploid cells too. The sensitivity of the adjuvant use of DNA‐image cytometry was 70% and the positive predictive value was 87.5%. Conclusions: The additional use of DNA‐image cytometry is a reasonable tool for the assessment of the resection margins of SCCs. DNA‐image cytometry could help to find the appropriate treatment option for the patients and thus might improve their prognosis.