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Investigation of functional gene polymorphisms: IL‐1B , IL‐6 and TNFA in benign migratory glossitis in Brazilian individuals
Author(s) -
Guimarães André Luiz Sena,
CorreiaSilva Jeane de Fátima,
Diniz Marina Gonçalves,
Xavier Guilherme Machado,
Horta Martinho Campolina Rebello,
Gomez Ricardo Santiago
Publication year - 2007
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2007.00559.x
Subject(s) - genotype , univariate analysis , medicine , interleukin 6 , multivariate analysis , univariate , case control study , etiology , polymorphism (computer science) , disease , multivariate statistics , gastroenterology , biology , pathology , genetics , gene , cytokine , statistics , mathematics
Background: Benign migratory glossitis (BMG) is a very common immunological oral disease of unknown aetiology. Methods and subjects: Fifty‐three consecutive subjects affected by BMG and 53 age‐ and sex‐matched control subjects were genotyped for IL‐1B , IL‐6 and TNFA polymorphisms. Binary logistic regression models were fitted and values of P < 0.05 were considered significant. Results: A significant difference in the distribution of IL‐1B genotypes was observed in the group with BMG in univariate analyses ( P = 0.01). The multivariate analyses showed that the CT genotype of the IL1‐B gene was significantly associated with a high risk to develop BMG ( P = 0.02, OR 2.76). The combined presence of IL‐1β high and intermediate producers genotypes was also associated with BMG in multivariate analyses ( P = 0.01, OR 3.05). IL‐6 and TNFA polymorphisms were not associated with BMG in the univariate and multivariate analyses. Conclusion: Our findings demonstrate that the polymorphism +3954 IL‐1B is associated with an increased risk of BMG development and suggest a genetic basis for disease development.