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Non‐calcifying variant of calcifying epithelial odontogenic tumor with Langerhans cells
Author(s) -
Wang Y.P.,
Lee J.J.,
Wang J.T.,
Liu B.Y.,
Yu C.H.,
Kuo R.C.,
Chiang C.P.
Publication year - 2007
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2007.00533.x
Subject(s) - pathology , eosinophilic , calcification , maxilla , stroma , odontogenic tumor , myoepithelial cell , anatomy , biology , lesion , medicine , immunohistochemistry
Calcifying epithelial odontogenic tumor (CEOT) is a rare type of odontogenic tumor. The most characteristic feature of the classical CEOT is the presence of amyloid globules and Liesegang ring calcification in the tumor tissue. Here, we present a non‐calcifying variant of intraosseous CEOT with the presence of Langerhans cells within tumor epithelial nests in a 52‐year‐old Taiwanese woman. The patient was referred from a local dentist to our hospital for treatment of a unilocular radiolucent lesion at the right anterior region of the maxilla. The lesion was excised. Microscopically, the tumor was composed of small nests or strands of odontogenic epithelial cells and amorphous eosinophilic globules of amyloid‐like materials in a loose fibrous connective tissue stroma. The tumor epithelial cells were positive for pan‐cytokeratins (AE1 and AE3). Langerhans cells demonstrated by anti‐CD1a staining were found in nests or strands of tumor epithelial cells. The eosinophilic globules were positive for Congo red and showed green birefringence when subjected to polarized light. Review of the English literature revealed two cases of non‐calcifying variant of intraosseous CEOT with Langerhans cells in the anterior and premolar regions of the maxilla. Taken together, we suggest that the non‐calcifying, Langerhan cell‐rich variant of CEOT may have a distinct predilection for occurrence in the anterior and premolar region of the maxilla in contrast to the classical CEOTs that usually occur in the molar and ascending ramus area of the mandible.