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Detection of antibodies against p63 and p73 isoforms in sera from patients diagnosed with oral lichen planus
Author(s) -
Ebrahimi Majid,
Wahlin YlvaBritt,
Coates Philip J.,
Wiik Allan,
Roos Göran,
Nylander Karin
Publication year - 2007
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2007.00504.x
Subject(s) - oral lichen planus , etiology , antibody , gene isoform , autoimmunity , western blot , medicine , transactivation , autoimmune disease , oral mucosa , immunology , disease , pathology , dermatology , biology , gene , transcription factor , biochemistry
Background: Oral lichen planus (OLP) is a chronic inflammatory disease of oral mucosa. Despite numerous publications and intense research, the etiology of OLP is still unknown, however, autoimmunity as a possible causative factor has been discussed. Methods: In the present study sera from 20 patients clinically and histologically diagnosed with OLP were analyzed for antibodies directed toward p53, p63, and p73 using Western blot. Results: Sera from two patients reacted with all six p63 isoforms, and one also with p73. The strongest reaction was noted against the TAp63 β protein, which is the most potent transactivator of all p63 proteins and is implicated in the differentiation of stratified epithelia. Conclusions: This is the first demonstration of antibodies directed against all p63 and some p73 isoforms in sera from patients diagnosed with OLP.