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Increased survivin expression in high‐grade oral squamous cell carcinoma: a study in Indian tobacco chewers
Author(s) -
Jane C.,
Nerurkar A. V.,
Shirsat N. V.,
Deshpande R. B.,
Amrapurkar A. D.,
Karjodkar F. R.
Publication year - 2006
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2006.00473.x
Subject(s) - survivin , immunohistochemistry , leukoplakia , medicine , malignancy , apoptosis , cancer , pathology , staining , cancer research , biology , biochemistry
Background: Oral cancer is one of the five leading sites of cancer in the Indian population. In the present study we analyzed the expression of apoptosis regulating genes, viz. survivin, Bcl‐2, Bax and p53 in precancerous and cancerous lesions of the buccal mucosa of Indian tobacco chewers. Method: Paraffin‐embedded tissue samples from 38 patients with primary oral squamous cell carcinoma (OSCC) and 17 patients with leukoplakia were used. The expression of survivin, Bcl‐2, Bax, and p53 was evaluated using immunohistochemical staining method. Results: Thirty‐six percent OSCC were found to be positive for nuclear p53 staining while none of the precancerous lesions showed p53 positivity. Survivin, Bcl‐2 and Bax expression was found to increase with increased grade of malignancy. Increase in survivin expression was statistically most significant ( P < 0.001). Conclusion: Increased expression of anti‐apoptotic survivin in high‐grade tumors suggests that survivin is likely to contribute significantly to apoptosis resistance in response to therapy.