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Immunohistological evaluation of Ki‐67, p63, CK19 and p53 expression in oral epithelial dysplasias
Author(s) -
Takeda T.,
Sugihara K.,
Hirayama Y.,
Hirano M.,
Tanuma JI.,
Semba I.
Publication year - 2006
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2006.00444.x
Subject(s) - grading (engineering) , epithelial dysplasia , pathology , dysplasia , basal (medicine) , epithelium , proliferation index , biology , basal cell , immunohistochemistry , keratin , basal cell carcinoma , carcinoma , proliferation marker , proliferating cell nuclear antigen , medicine , ecology , insulin , endocrinology
Background: Oral squamous cell carcinoma develops through a multistep of genetic mutations, and the process can be morphologically recognized as oral epithelial dysplasia. To evaluate the hypothesis that distributional alterations of proliferating and stem cells may be a useful index to estimate the grading and development of epithelial dysplasia, we examined the distribution patterns according to stratified cell layers. Methods: Sixty‐two oral dysplasia cases according to the histological grades were immunohistologically examined and the nuclear expression of Ki‐67 and p63 antigens was counted according to epithelial layers as labeling index. Results: The Ki‐67 labeling index in the basal and suprabasal layers and that of p63 in the basal layer showed a significant difference between low‐ and high‐grade groups of epithelial dysplasia. Conclusion: The architectural alteration of proliferating cell and stem cell distribution in the layers of epithelial dysplasias may provide useful information to evaluate the grading of oral epithelial dysplasias.