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The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration
Author(s) -
Nolan A.,
Baillie C.,
Badminton J.,
Rudralingham M.,
Seymour R. A.
Publication year - 2006
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2006.00433.x
Subject(s) - medicine , placebo , hyaluronic acid , randomized controlled trial , dermatology , surgery , placebo controlled study , double blind , alternative medicine , pathology , anatomy
Background: The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) preparation (0.2%) in the management of recurrent aphthous ulceration (RAU). Methods: One hundred and twenty patients with RAU participated in a randomized, placebo controlled, double‐blind trial to evaluate the efficacy of the topical HA and preparation. Outcome measures include soreness relief on immediate application (recorded over 60 min). Thereafter, patients completed a log diary recording soreness from the ulcers, occurrence of new ulcers and ulcer duration. Results: Both topical HA and placebo resulted in a significant reduction in ulcer soreness following immediate application ( P = 0.0004). Throughout the rest of the investigation period, there was no significant differences ( P > 0.05) between the treatments for reducing soreness. Patients treated with topical HA recorded few ulcers on day 5 of the investigation than those treated with placebo ( P < 0.001). Likewise, the occurrence of new ulcers was lower in the HA treated group on day 4 when compared with placebo ( P = 0.047). Conclusion: Topical HA (0.2%) may be of benefit in the management of RAU. Immediate reduction of symptoms appears to be a barrier effect.