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Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts
Author(s) -
Stoll Christian,
Stollenwerk Carolin,
Riediger Dieter,
Mittermayer Christian,
Alfer Joachim
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2005.00352.x
Subject(s) - radicular cyst , odontogenic , dentigerous cyst , pathology , cytokeratin , keratocyst , adenomatoid odontogenic tumor , immunohistochemistry , differential diagnosis , medicine , context (archaeology) , odontogenic cyst , clinical significance , ameloblastoma , biology , dentistry , molar , paleontology
Background: The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive. Methods: Thirty cases of dentigerous and radicular cysts respectively as well as 15 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki‐67 immunohistochemically. Results: Expression of CK 17 was discernible in 93.3% of the odontogenic keratocysts, but only in 35.0% of dentigerous and radicular cysts under study ( P < 0.001). CK 19 could be detected in 48.3% of dentigerous and radicular cysts, whereas odontogenic keratocysts were completely negative ( P < 0.002). Conclusion: Immunohistochemical detection of CK 17 and 19 seems to be a valuable additional parameter distinguishing between odontogenic keratocysts and other odontogenic – especially dentigerous – cysts which clinically are likely the most significant differential diagnoses in this context.