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Electrophoretically separation of the synovial fluid proteins in rabbit temporomandibular arthritis induced by mechanical loading
Author(s) -
Fujimura K.,
Kobayashi S.,
Yoshitake Y.,
Tsuruoka N.,
Kaneyama K.,
Segami N.
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2005.00350.x
Subject(s) - synovial fluid , temporomandibular joint , arthritis , medicine , rabbit (cipher) , chemistry , pathology , endocrinology , osteoarthritis , alternative medicine , statistics , mathematics
Background: The concentration of protein in synovial fluid (SF) of temporomandibular joints (TMJs) with disorders tends to be increased. We investigated the protein composition of SF of rabbits in which arthritis of the TMJ was induced. Method: Arthritis was induced in six TMJs in six rabbits by exertion of a load for 4 weeks. Six non‐loaded TMJs in six rabbits served as controls. The protein concentration and content in TMJ SF of the two groups were compared. Results: The mean protein concentration was higher in the SF of the loaded group than in that of the non‐loaded group (1824 μ g/ml vs. 398 μ g/ml, P = 0.002). Proteins with molecular weights of more than 95 kDa were abundant in the loaded group ( P < 0.05). Conclusion: Temporomandibular arthritis induced by mechanical loading in rabbit is accompanied by an increase in the abundance of relatively high molecular weight proteins in SF.