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A comparative study of the efficacy of Aphtheal TM in the management of recurrent minor aphthous ulceration
Author(s) -
Murray Brenda,
McGuinness Niall,
Biagioni Paul,
Hyland Paula,
Lamey PhilipJohn
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2005.00334.x
Subject(s) - medicine , gastroenterology , surgery
Background: Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin. Methods: This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal TM (5% amlexanox paste) to determine if ulcer development could be prevented. A second arm of the study investigated treatment of RAU with Aphtheal TM once ulceration had developed. Ulcer duration, ulcer size and associated pain were measured. Both groups of subjects had previously undergone a no‐treatment run‐in period to establish these parameters over an untreated episode of ulceration. Results: By day 3, only 35% of the prodromal group had developed an ulcer compared with 97% of the ulcer group ( P < 0.001). In the treated ulcer group only 66% had an ulcer present by day 3. Treatment at the onset of prodromal symptoms reduced the maximum ulcer size score by 84% ( P < 0.01), extent of ulceration by 88% ( P < 0.01), maximum pain score by 69% ( P < 0.01) and extent of pain by 85% ( P < 0.01) compared to no treatment. Conclusion: Treatment with Aphtheal TM at the onset of prodromal RAU symptoms can prevent progression to ulcer development and significantly reduced symptoms if ulcers do develop.