Premium
Expression of IgSF in salivary adenoid cystic carcinoma and its relationship with invasion and metastasis
Author(s) -
Xue Fan,
Zhang Yincheng,
Liu Feng,
Jing Jie,
Ma Min
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2005.00312.x
Subject(s) - immunoglobulin superfamily , neural cell adhesion molecule , cell adhesion molecule , adenoid cystic carcinoma , metastasis , cell adhesion , immunohistochemistry , pathology , biology , intercellular adhesion molecule 1 , vcam 1 , cancer research , icam 1 , carcinoma , cell , immunology , cancer , medicine , biochemistry , genetics
Background: The aim of the present work was to study the potential effect of intercellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1) and neural cell adhesion molecule (NCAM) of immunoglobulin superfamily on the invasion and metastasis of salivary adenoid cystic carcinoma (SACC). Method: The expressions of ICAM‐1, VCAM‐1 and NCAM of forty cases with SACC were examined by immunohistochemical methods using respective kits. Results: A significant relation showed between the expression level and histological differentiation, expression of ICAM‐1 and VCAM‐1 in solid SACC was greatly increased compared with NCAM; SACC with metastatic lymph node or local recurrence displayed significant relationship to the up‐regulation of ICAM‐1 and VCAM‐1, and to the down‐regulation of NCAM. Conclusions: It is proposed that ICAM‐1 and VCAM‐1 may play a role in the invasion and metastasis of SACC. NCAM may be an invasion‐resistant adhesion molecule.