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Oxpentifylline is not effective for symptomatic oral lichen planus
Author(s) -
Wongwatana Sasiwong,
Leao Jair C.,
Scully Crispian,
Porter Stephen
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2004.00278.x
Subject(s) - oral lichen planus , medicine , adverse effect , dermatology , surgery
Background: There are no reliably effective therapies for oral lichen planus (OLP). The aim of the present work was to determine the potential efficacy of oxpentifylline in the management of OLP. Methods: Fifteen patients (six males, median age for the group 52 years, ranging from 33 to 72) with clinically and histopathologically confirmed OLP were treated with oxpentifylline at a dose of 400 mg three times daily. Results: Only 10 patients completed an 8 week course, the other five having to stop therapy because of adverse effects. Only three patients had any relief of their signs and symptoms of OLP. Conclusion: The results indicate that oxpentifylline is unlikely to be of benefit for the treatment of OLP.