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MMP‐3 and ‐8 expression is found in the condylar surface of temporomandibular joints with internal derangement
Author(s) -
Tiilikainen P.,
Pirttiniemi P.,
Kainulainen T.,
Pernu H.,
Raustia A.
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2004.00262.x
Subject(s) - derangement , temporomandibular joint , condyle , matrix metalloproteinase , medicine , orthodontics , dentistry , pathology , mathematics , combinatorics
Background: Internal derangement is one of the most common disorder of the temporomandibular joint (TMJ). The aim of this study was to investigate the associations of matrix metalloproteinase (MMP)‐3 and ‐8 expression in articular condylar surface with different stages of TMJ internal derangement according to Wilkes ( Minn Med , 1978; 61 : 645–52) and osteoarthrosis (OA) according to Dijkgraaf et al. ( J Oral Maxillofac Surg , 1995; 53 : 1182–92). Methods: The study was based on 54 condylar specimens obtained during TMJ surgery. Immunohistochemistry using antibodies specific to MMP‐3 and ‐8, represented in cartilage destruction, was carried out. Results: In all tissue specimens, MMP‐3 expression was intense in the surface layer but showed less intensive staining in the deeper layers. Some MMP‐8 expression was also seen. The severity of TMJ internal derangement, however, did not seem to have a statistically significant correlation ( P < 0.05) with the expression of these enzymes. Conclusion: The study confirms that distinct expression of MMP‐3 and ‐8 is found in the condylar surface of TMJs with internal derangement.