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Angiolipoma of the buccal mucosa: a possible role of mast cell‐derived VEGF in its enhanced vascularity
Author(s) -
IdaYonemochi Hiroko,
Swelam Wael,
Saito Chikara,
Saku Takashi
Publication year - 2005
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2004.00230.x
Subject(s) - vascularity , pathology , connective tissue , buccal mucosa , vascular endothelial growth factor , infiltration (hvac) , blood vessel , buccal administration , anatomy , mast cell , medicine , vegf receptors , immunology , materials science , oral cavity , composite material , orthodontics , pharmacology
A case of angiolipoma occurring in the buccal mucosa of a 69‐year‐old male is described. The patient had noticed a painless mass in his buccal mucosa for 2 years. The surgically removed tumor, measuring 9 mm in diameter, was mainly located in the submucosal layer with focal expansion into the muscle layer. Histologically, the tumor was well‐demarcated and composed of proliferations of mature fat cells and fibrous connective tissue containing many small blood vessels, which were evenly distributed. There was diffuse infiltration of a large number of mast cells, which were immunopositive for vascular endothelial growth factor (VEGF) especially around blood vessels, suggesting that VEGF produced by mast cells in angiolipomas plays an important role in the vascular proliferation in this particular tumor.