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Involvement of tumor necrosis factor‐α and interleukin‐8 in antigen‐induced arthritis of the rabbit temporomandibular joint
Author(s) -
Sukedai Miho,
Tominaga Kazuhiro,
Habu Manabu,
Matsukawa Akihiro,
Nishihara Tatsuji,
Fukuda Jinichi
Publication year - 2004
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.2004.00008.x
Subject(s) - temporomandibular joint , medicine , tumor necrosis factor alpha , arthritis , antigen , rabbit (cipher) , tumor necrosis factor α , interleukin , pathology , immunology , cytokine , statistics , mathematics
Background: In temporomandibular joint (TMJ) arthritis, knowledge is limited about the source of the inflammatory mediators. The aim of this study was to investigate the immunohistochemical role of tumor necrosis factor‐α (TNF‐α) and interleukin‐8 (IL‐8) in the development of the antigen‐induced arthritis of the rabbit TMJ. Methods: Unilateral TMJ arthritis was induced in 28 adult rabbits. From 6 h to 6 weeks after induction of arthritis, the topology of TNF‐α and IL‐8 was observed. Results: Positive reaction for TNF‐α of synovial cells was observed within 3 days after induction and at 3 weeks after induction. TNF‐α positive vascular endothelial cells and chondrocytes were identified throughout the observation period. IL‐8 was detected only during the acute stage. Conclusions: The cytokines TNF‐α and IL‐8 were observed in specific cells depending on the stage. TNF‐α was particularly related with angiogenesis and cartilage destruction and IL‐8 was involved in the acute stage of inflammation.