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Systemic absorption of lidocaine after topical application for the treatment of oral mucositis in bone marrow transplantation patients
Author(s) -
Elad Sharon,
Cohen Galit,
ZylberKatz Ester,
Findler Moti,
Galili Dan,
Garfunkel Adi A.,
Or Reuven
Publication year - 1999
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1999.tb02018.x
Subject(s) - mucositis , lidocaine , medicine , topical anesthetic , local anesthetic , oral mucosa , anesthesia , fluorescence polarization immunoassay , lidocaine hydrochloride , transplantation , absorption (acoustics) , surgery , chemotherapy , pathology , physics , acoustics
This paper evaluates lidocaine absorption via oral mucosa following its topical application for symptomatic treatment of bone marrow transplantation (BMT)‐induced oral mucositis. Five patients with high‐grade oral mucositis after allogeneic BMT were entered consecutively into the study. Five healthy individuals served as controls. All 10 participants rinsed their mouth with 5ml of a 2% lidocaine solution for 1 min, after which they expectorated the liquid. Blood samples were drawn at 1, 5, 10, 20, 30 and 60 min after rinsing and centrifuged. Plasma lidocine levels were measured by fluorescence polarization immunoassay. In the BMT patients, plasma lidocaine levels were lower than the therapeutic range of this drug (0.2 μg/ml), while in the controls no detectable lidocaine levels were noted. The data from this preliminary study indicate that lidocaine prescribed as an anesthetic mouthwash in BMT patients with oral mucositis results in minor systemic absorption of the drug.