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Suppression of Fas receptor and negative correlation of Fas ligand with differentiation and apoptosis in oral squamous cell carcinoma
Author(s) -
Loro Lado Lako,
Vintermyr Olav Karsten,
Johannessen Anne Christine,
Liavaag Per Gunnar,
Jonsson Roland
Publication year - 1999
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1999.tb02001.x
Subject(s) - fas ligand , apoptosis , basal (medicine) , tunel assay , fas receptor , biology , basal cell , immunohistochemistry , pathology , programmed cell death , receptor , epidermoid carcinoma , cancer research , microbiology and biotechnology , immunology , endocrinology , medicine , biochemistry , insulin
Apoptosis and the expression of Fas receptor (Fas) and Fas ligand (FasL) were studied in 8 samples of normal oral mucosa (OM) and in 19 oral squamous cell carcinomas (OSCC) by immunohistochemistry and the TUNEL method. Fas was detected in less than 2% of cells of OSCC compared with 84.3 ± 9.0% of cells in the basal layer in OM. FasL was found to be highly expressed in poorly differentiated lesions (90.9 ± 3.6%), and in cells of both the basal (88.3 ± 4.3%) and central (85.3 ± 5.7%) parts of moderately differentiated lesions, whereas in well‐differentiated (WD) lessions expression was considerably lower in both basal (42.7 ± 4.1%) and central (11.5 ± 2.4%) parts. In normal OM FasL was primarily detected in cells of the basal layer, but in a high proportion of cells (84.9 ± 4.3%). Apototic cell death was greater in OSCC (1.6 ± 0.6%) than in OM (0.6 ± 0.2%, P <0.05) and was most pronounced in the central part of WD OSCC (2.3 ± 0.5%). Our results show that Fas is expressed in low quantities in OSCC and that FasL expression correlates negatively with degree of differentiation and apoptosis in OSCC.