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Expression of p53 protein correlates with decreased survival in patients with areca quid chewing and smoking‐associated oral squamous cell carcinomas in Taiwan
Author(s) -
Chiang ChunPin,
Huang JehnShyun,
Wang JengTzung,
Liu BuYuan,
Kuo YingShiung,
Hahn LiangJiunn,
Kuo Mark YenPing
Publication year - 1999
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1999.tb01999.x
Subject(s) - areca , medicine , basal cell , gastroenterology , immunoperoxidase , cancer , lymph node , p53 protein , oncology , immunohistochemistry , pathology , antibody , monoclonal antibody , immunology , structural engineering , nut , engineering
Expression of p53 protein was examined in oral squamous cell carcinoma (SCC) from patients who were areca quid (AQ) chewers and/or tobacco smokers, using anti‐p53 antibodies with an immunoperoxidase technique. Positive p53 stain was observed in 47 of 81 (58%) cases of oral SCC. p53 overexpression was found to higher in patients without AQ chewing and smoking habits than in patients with these two habits (80% vs 52%, P=0.076). No significant correlation was found between p53 expression and the patients' age, sex, cancer location, clinical staging, primary tumor TNM status, or histological differentiation of SCC. The Kaplan‐Meier analysis showed that the prognosis for patients with p53‐negative tumors was significantly better than that for patients with p53‐positive tumors (P<0.05). A significant correlation was also observed between positive lymph node status and poor prognosis (P<0.05). These results suggest that p53 may serve as an adjuvant marker of poor survival in patients with oral SCCs in Taiwan.