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Histological effects and predictive biomarkers of TPP induction chemotherapy for oral carcinoma
Author(s) -
Hamakawa Hiroyuki,
Bao Yang,
Takarada Manabu,
Tanioka Hiroaki
Publication year - 1998
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1998.tb02100.x
Subject(s) - chemotherapy , cisplatin , medicine , proliferating cell nuclear antigen , induction chemotherapy , pathology , cancer , oncology , lymph , carcinoma , gastroenterology , immunohistochemistry
Hamakawa H, Bao Y, Takarada M, Tanioka H: Histological effects and predictive biomarkers of TPP induction chemotherapy for oral carcinoma. J Oral Pathol Med 1998; 27: 87–94. © Munksgaard, 1998. The effects of an induction chemotherapy with THP‐adriamycin, cisplatin, and peplomycin (TPP) were studied in 32 patients with operable oral cancer. The histological evaluation according to the Shimozato‐Oboshi classification was Grade (G) IV in ten cases (31.3%), GUI in one case, and Glib in four cases. Induction of apoptosis and differentiation‐inducing effects, hyperkeratinization or bone formation, were observed in some cases. The overall clinical response rate and histological response rate were 63% and 47%, respectively. Grade III was obtained in seven metastatic lymph nodes of three patients. The expressions of PCNA, p53, and AgNORs before and after chemotherapy were studied. The prechemotherapeutic PCNA positive cell index (PI) of the highly responsive tumors (GUI, IV) was significantly lower than that of the poorly responsive tumors (G0‐Ilb) ( P < 0.01). Similar results were obtained in the evaluation of p53 PI ( P < 0.05), suggesting that PCNA and p53 are useful biomarkers for predicting the efficacy of TPP chemotherapy.