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Assessment of growth potential by MIB‐1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma
Author(s) -
Sano Kazuo,
Yoshida Shinichi,
Ninomiya Hidenori,
Ikeda Hisazumi,
Ueno Kei,
Sekine Joji,
Iwamoto Hiroaki,
Uehara Masataka,
Inokuchi Tsugio
Publication year - 1998
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1998.tb02094.x
Subject(s) - immunohistochemistry , pathology , fibrosarcoma , odontogenic tumor , medicine , biology , lesion
Sano K, Yoshida S, Ninomiya H, Ikeda H, Ueno K, Sekine J, Iwamoto H, Uehara M, Inokuchi T: Assessment of growth potential by MIB‐1 immunohistochemistry in ameloblastic fibroma and related lesions of the jaws compared with ameloblastic fibrosarcoma. J Oral Pathol Med 1998; 27: 59–63. © Munksgaard, 1998. Specimens from two ameloblastic fibromas (including one recurrent case), two ameloblastic fibro‐odontomas, and one ameloblastic fibrosarcoma were subjected to investigation by MIB‐1 immunohistochemistry in order to elucidate the growth potential of these tumors. MIB‐1 labeling indices in the epithelial component of these tumors ranged from 2.9 to 7.5%, whereas those in the mesenchymal component ranged from 1.5 to 13.5%. Of these, labeling indices in the mesenchymal component of the recurrent ameloblastic fibroma and ameloblastic fibrosarcoma were quite high. These findings suggest that evaluation of growth potential in ameloblastic fibroma and related lesions could be of help in understanding tumor aggressiveness and in selecting appropriate surgical procedures.