Premium
Significant correlation between matrix metalloproteinase activity and tumor necrosis factor‐oc in salivary extravasation mucoceles
Author(s) -
Hoque Mohammad Obaidul,
Azuma Masayuki,
Sato Mitsunobu
Publication year - 1998
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1998.tb02087.x
Subject(s) - extravasation , matrix metalloproteinase 9 , pathology , medicine , salivary gland , matrix metalloproteinase , tumor necrosis factor alpha , tumor necrosis factor α , necrosis , matrix (chemical analysis) , chemistry , chromatography
Hoque MO, Azuma M, Sato M: Significant correlation between matrix metalloproteinase activity and tumor necrosis factor‐a in salivary extravasation mucoceles. J Oral Pathol Med 1998; 27: 30–3. © Munksgaard, 1998. We examined the matrix metalloproteinase (MMP) activity and tumor necrosis factor (TNF)‐a in luminal fluid of 18 extravasation mucoceles and in saliva from Wharton's duct of five patients by means of gelatin zymography and enzyme immunoassay, respectively. The luminal fluid showed a high level of MMP activity compared with the saliva. Quantitative determination by enzyme immunoassay revealed that the luminal fluid contained higher levels of TNF‐a than the saliva. In addition, the amount of TNF‐a in luminal fluid exhibited a direct correlation with MMP activity estimated by densitometric analysis of gelatin zymograms. Since TNF‐a stimulates the production of MMPs from cells such as fibroblasts, these results suggest that TNF‐a is one of the causal molecules that enhance the accumulation of proteolytic enzymes in luminal fluid of mucoceles.