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Clear cell odontogenic tumour: a case with induction of dentin‐like structures?
Author(s) -
Miyauchi Mutsumi,
Ogawa Ikuko,
Takata Takashi,
Ito Hiroshi,
Nikai Hiromasa,
Ijuhin Naokuni,
Tanimoto Keiji,
Itoh Yoshiaki
Publication year - 1998
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1998.tb01945.x
Subject(s) - pathology , cytokeratin , hyaline , immunohistochemistry , eosinophilic , odontogenic tumor , connective tissue , biology , mesenchymal stem cell , epithelium , medicine , odontogenic
A case of clear cell odontogenic tumour, which occurred centrally in the mandible of a 56‐year‐old Japanese woman, is reported with its histochemical, immunohistochemical and ultrastructural findings. Histologically, the tumour nests were composed of large glycogen‐rich clear cells and small non‐clear polygonal cells and were separated by thin mature fibrous connective tissue septae. Immunohistochemically, both types of tumour cells showed positive expression of various cytokeratins, in particular cytokeratin 19, and of epithelial membrane antigen. Eosinophilic hyaline deposits and possible dentin‐like structures were occasionally formed in contact with the epithelial nests and are regarded as indicative of the epithelial‐mesenchymal inductive capacity of this tumour. The aggressive nature of the present tumour was assumed through its invasive growth pattern and occasional mitotic figures. Although it was diagnosed as clear cell odontogenic tumour according to the present WHO classification, the patient must be followed carefully because of its probable malignant nature.