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Spindle cell carcinoma of the gingiva: report of an autopsy case
Author(s) -
Munakata Ryuchi,
Cheng Jun,
Nakajima Tamio,
Saku Takashi
Publication year - 1998
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1998.tb01937.x
Subject(s) - pathology , spindle cell carcinoma , sarcomatoid carcinoma , anaplastic carcinoma , carcinoma , lymph node , autopsy , vimentin , medicine , epidermoid carcinoma , immunohistochemistry
An autopsied case of an 80‐year‐old man with spindle cell carcinoma of the gingiva is reported. The tumor was polypoid and mostly composed of a sarcomatous proliferation of spindle cells with a small focus of squamous cell carcinoma at the stalk portion. The carcinoma metastasized to a cervical lymph node, lungs and pleura with extension to the diaphragm. In the metastatic lymph node, the squamous cell component was more prominent than the spindle cell one, while only anaplastic pleomorphic carcinoma cells were found in the lungs. The spindle or anaplastic cells were immunohistochemically positive for vimentin and carci‐noembryonic antigen (CEA) but not for other epithelial antigens. We have concluded that the sarcomatoid component arose from the oral squamous cell carcinoma by a metaplastic process. This is the first case report of an oral spindle cell carcinoma examined by autopsy.