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Features of odontogenesis and expression of cytokeratins and tenascin–C in three cases of extraosseous and intraosseous calcifying odontogenic cyst
Author(s) -
Lukinmaa PirjoLiisa,
Leppaniemi Anu,
Hietanen Jarkko,
Allemanni Giorgio,
Zardi Luciano
Publication year - 1997
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1997.tb01235.x
Subject(s) - pathology , cytokeratin , immunostaining , biology , epithelium , tenascin , immunohistochemistry , anatomy , keratin , staining , connective tissue , odontogenic cyst , cyst , medicine , extracellular matrix , microbiology and biotechnology , fibronectin
To characterize further the nature of calcifying odontogenic cyst (COC), we studied histologically and immunohistochemically an extraosseous and two intraosseous lesions. The extraosseous COC was in continuity with the stratified squamous epithelium of the alveolar mucosa. Immunostaining with monoclonal antibodies showed reactivity of both low‐ and high‐molecular‐weight cytokeratins, the degree of coexpression decreasing with the increasing morphological diversity of the cyst/tumour epithelium. Staining for the matrix glycoprotein tenascin‐C was seen not only in the connective tissue, where its distribution patterns corresponded to the stage of hard tissue formation, but also in epithelial elements. The staining patterns were analogous to those described during normal tooth formation. Both the morphological characteristics and expression patterns of the various cytokeratin types and tenascin‐C implied that COC represents a pathological counterpart of normal odontogenesis. In the case of the extraosseous COC, the correspondence could he traced back to early stages of tooth development.