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Immunohistochemical demonstration of bcl‐2 protein in ameloblastoma
Author(s) -
Mitsuyasu Takeshi,
Harada Hidemitsu,
Higuchi Yoshinori,
Kimura Kenichi,
Nakamura Norifumi,
Katsuki Takeshi,
Kubola Eiro,
Toyoshima Kuniaki,
Ohishi Masamichi
Publication year - 1997
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1997.tb00228.x
Subject(s) - ameloblastoma , immunohistochemistry , biology , pathology , monoclonal antibody , population , adamantinoma , mesenchymal stem cell , antibody , microbiology and biotechnology , immunology , medicine , anatomy , maxilla , environmental health
The bcl‐2 gene is known through its product, bcl‐2 protein, which prevents apoptosis. and also by its expression in development, especially in sites characterized by epithelial‐mesenchymal interactions. In the developing tooth germ, bcl‐2‐protein is expressed in the epithelial component. In this study, we examined the expression of bcl‐2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti‐human bcl‐2 oncoprotein. In all 25 cases, bcl‐2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum‐like cells and squamoid cells) were negative. The bcl‐2 protein is therefore thought to play a role in maintaining the stem‐cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.