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GB virus infection in patients with oral cancer and oral lichen planus
Author(s) -
Nagao Yumiko,
Sata Michio,
Noguchi Seiji,
Suzuki Hiroshi,
Mizokami Masashi,
Kameyama Tadamitsu,
Tanikawa Kyuici
Publication year - 1997
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1997.tb00037.x
Subject(s) - oral lichen planus , hepatitis c virus , cancer , medicine , virus , antibody , incidence (geometry) , immunology , physics , optics
We studied the incidence of GBV‐C infection in patients with oral cancer or oral lichen planus (OLP). Subjects included 38 patients with oral cancer and 34 patients with OLP from whom serum was collected to detect GBV‐C‐RNA using reverse transcription (RT) “nested” PCR. GBV‐C‐RNA was positive in 1 (2.6%) oral cancer patient and 3 (8.8%) OLP patients. All 4 GBV‐C‐positive patients were also positive both for the antibody for hepatitis C virus (anti‐HCV) and HCV‐RNA, indicating simultaneous infection with GBV‐C and HCV. In conclusion. GBV‐C infection was found in 5.5% (4/72) of oral cancer or OLP patients and all patients infected with GBV‐C also had HCV infection. This suggests that GBV‐C infection is unlikely to play an important role in the pathogenesis of oral cancer and OLP.