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Raised levels of circulating VCAM‐1 and circulating E‐selectin in patients with recurrent oral ulceration
Author(s) -
Healy C.M.,
Enobakhare B.,
Haskard D.O.,
Thornhill M.H.
Publication year - 1997
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1997.tb00005.x
Subject(s) - cell adhesion molecule , vcam 1 , soluble cell adhesion molecules , e selectin , cell adhesion , medicine , adhesion , immunology , selectin , endothelial activation , inflammation , pathology , cell , icam 1 , chemistry , biochemistry , organic chemistry
Endothelial cell (EC) adhesion molecules VCAM‐1 (vascular cell adhesion molecule‐1). E‐selectin and 1CAM‐1 (intercellular adhesion molecule‐1) are essential for the binding of inflammatory cells to ECs. Recently, circulating forms of these molecules have been detected in a number of vasculitic disease processes. Recurrent oral ulceration (ROU I has some features of a vasculitic disease process. The purpose of this study was. therefore, lo compare cVCAM‐1, cE‐selectin and cICAM‐1 levels in 50 patients with ROU and 50 age‐ and sex‐matched controls. Levels of circulating adhesion molecules were quantified using specific “sandwich” ELISA assays. The cVCAM‐J and cE‐selectin levels were significantly raised in ROU patients ( P < 0.00005 and P < 0.05, respectively) but there was no significant increase in cICAM‐1 levels. These findings may result from endothelial cell activation or damage at the ulcer site.