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Reduced expression of dipeptidyl peptidase (DPP) IV in peripheral blood T lymphocytes of oral cancer patients
Author(s) -
Uematsu Takashi,
Urade Masahiro,
Yarnaoka Minoru,
Yoshioka Wataru
Publication year - 1996
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1996.tb00306.x
Subject(s) - medicine , cancer , dipeptidyl peptidase , peripheral blood , endocrinology , dipeptidyl peptidase 4 , t lymphocyte , lymphocyte , peripheral , immunology , immune system , enzyme , diabetes mellitus , biology , type 2 diabetes , biochemistry
To investigate the mechanism of decrease of serum DPP IV activity in oral cancer patients, we analyzed the expression of DPP IV in peripheral blood T lymphocytes of oral cancer patients and healthy subjects. Consequently, serum DPP IV activity was found to correlate significantly with the number of peripheral blood lymphocytes (PEL). T lymphocytes and CD26 (identified as DPP IVT T lymphocytes in healthy subjects, and the number of PEL and CD26T T lymphocytes in cancer patients. However, the numbers of PEL and T lymphocytes were significantly less in cancer patients than in healthy subjects. Although the number of CD26+ T lymphocytes was somewhat greater in cancer patients than in healthy subjects, serum DPP IV activity was significantly lower in cancer patients. DPP IV activity and amount of CD26+ in T lymphocyte plasma membranes were much less in cancer patients than in healthy subjects. These findings suggest that a decrease in the number of T lymphocytes and the small amount of DPP IV in their plasma membrane may contribute to the decrease of serum DPP IV activity in cancer patients.