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IL‐1α and IL‐6 production by oral and skin keratinocytes: similarities and differences in response to cytokine treatment in vitro
Author(s) -
Li J.,
Farthing P. M.,
Ireland G. W.,
Thornhill M. H.
Publication year - 1996
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1996.tb00213.x
Subject(s) - cytokine , stimulation , immunology , oral mucosa , in vitro , interleukin , tumor necrosis factor alpha , keratinocyte , medicine , biology , pathology , endocrinology , biochemistry
IL‐1α and IL‐6 are important pro‐inflammatory and immunomodulatory cytokines and their production by oral (OK) and skin keratinocytes (SK) was compared. OK and SK produced IL‐la, but not IL‐6, constitutively. TNFα stimulation increased IL‐la production by both cell types and exhibited synergy with interferon y (IFNγ). although the latter had no effect by itself. In contrast, both cell types produced IL‐6 in response to TNFα, IFNγ or IL‐4. and IFNγ and IL‐4 exhibited synergy with TNFα. For all cytokines the levels of IL‐6 production were greater for OK than SK and OK, but not SK, produced IL‐6 in response to IL‐1α stimulation. In addition, the IL‐6 response to IL‐4 stimulation was more rapid for OK than SK. These observations may explain the similarities and differences in wound healing and immuno‐inflammatory diseases affecting the skin and oral mucosa.