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Cyclosporin‐ and nifedipine‐induced gingival overgrowth in renal transplant patients: correlations with periodontal and pharmacological parameters, and HLA‐antigens
Author(s) -
Margiotta Valerio,
Pizzo Ignazio,
Pizzo Giuseppe,
Barbaro Adele
Publication year - 1996
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1996.tb00207.x
Subject(s) - medicine , nifedipine , azathioprine , gastroenterology , renal transplant , tacrolimus , microgram , kidney , transplantation , calcium , disease , in vitro , biochemistry , chemistry
The factors associated with Cyclosporin A (CsA)‐ and nifedipine (Nif)‐induced gingival overgrowth were investigated in 113 renal transplant recipients receiving CsA alone (Group 1) [ n = 61]. CsA and Nif (Group 2) [ n = 28], or azathioprine (Aza) (Control Group) [ n = 24]. Periodontal and pharmacological parameters were assessed for each patient. The patients with a gingival overgrowth index (GOI) score >1 were considered responders (R); those with a score ≥1 were non‐responders (NR). Gingival overgrowth occurred in 33.7% of the patients in Groups 1 and 2; 60% of the responders were receiving CsA+Nif. In R. no relationship was found between the GOI and the periodonial and pharmacological parameters, and although there was a trend towards an increased presence of HLA‐A19 antigen (chi‐square = 4.40: P = 0.04: RR = 2.86), no significant difference was found between R and NR ( Pc > 0.05). It is concluded that the prevalence and severity of gingival overgrowth are greater in patients receiving CsA+Nif. As overgrowth appeared to be unrelated to local irritants, gingival inflammation or pharmacological parameters, it may be related to individual susceptibility.