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Sensitivity and specificity of OraScan® toluidine blue mouthrinse in the detection of oral cancer and precancer
Author(s) -
Warnakulasuriya K.A.A.S,
Johnson Newell W.
Publication year - 1996
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1996.tb00201.x
Subject(s) - toluidine , medicine , cancer , pathology , carcinoma , gastroenterology , oral cancers , chemistry
The efficacy of 1% toluidine blue in the identification of oral malignancies and potentially malignant oral lesions was evaluated among a group of Asian patients ( n =102) with undiagnosed oral mucosal lesions and conditions (n=145). The trial, utilizing a ready‐to‐use kit, was controlled by histopathologic evaluation of a total of 87 dye‐retained or dye‐negative lesions. Eighteen oral carcinomas all retained the dye and there were no false negatives, yielding a test sensitivity of 100%. Eight of 39 oral epithelial dysplasias were toluidine blue‐negative, giving a false negative rate of 20.5% and a sensitivity of 79.5% for oral epithelial dysplasias. The specificity of the technique was low (62%). Five dysplastic lesions were detected solely by the kit and this suggests that the method is valuable for surveillance of high‐risk subjects in addition to its remarkable sensitivity in the detection of invasive carcinoma.