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Immunohistochemical observations on a possible ameloblastic fibro‐odontoma
Author(s) -
Miyauchi Mutsumi,
Takata Takashi,
Ogawa Ikuko,
Ito Hiroshi,
Nikai Hiromasa,
Ljuhin Naokuni,
Tanimoto Keiji,
Miyauchi Shinobu
Publication year - 1996
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1996.tb00200.x
Subject(s) - vimentin , pathology , immunohistochemistry , odontoma , odontogenic tumor , adamantinoma , enamel organ , connective tissue , mesenchymal stem cell , epithelium , biology , medicine , anatomy , ameloblastoma , enamel paint , maxilla , ameloblast , odontogenic , dentistry
An ameloblastic fibro‐odontoma which occurred in the mandible of a 3‐year‐old Japanese boy is reported together with immunohistochemical findings. Histologically, the tumor consisted of an ameloblastic fibroma‐like area and some typical complex odontoma‐like areas. The epithelial islands in the ameloblastic fibroma‐like area showed different developmental stages of the epithelial‐connective tissue interface. Immunohistochemical examination revealed that all epithelial components in the ameloblastic fibroma‐like area showed expression of CK 8, CKs 13, 16, CK 14, CK 18 and CK 19, and coexpression of these cytokeratins and vimentin. These findings suggest that even the epithelial component without obvious epithelial‐mesenchymal induction showed the final cell differentiation of the enamel organ with the potential for epithelial‐mesenchymal induction.