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Linear IgA disease (LAD): immunoglobulin deposition in oral and colonic lesions
Author(s) -
Cowan C. G.,
Lamey P.J.,
Walsh M.,
Irwin S. T.,
Allen G.,
McKenna K. E.
Publication year - 1995
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1995.tb01202.x
Subject(s) - medicine , immunoglobulin a , immunofluorescence , biopsy , inflammatory bowel disease , pathology , disease , antibody , gastroenterology , direct fluorescent antibody , immunology , immunoglobulin g
Two cases of adult linear IgA disease (LAD) with oral and colonic involvement are presented. Oral findings, for both patients, were of widespread painful ulceration present for two to three months and diagnosis was confirmed by biopsy and direct immunofluorescence. Colonic symptoms preceded oral symptoms in both cases and a number of investigations were undertaken, including routine histological examination, which suggested either lymphocytic colitis or Crohn's disease. Immunofluorescence studies showed linear IgA deposition confined to the distal colon. These cases highlight that large bowel involvement can be a feature of linear IgA disease and for the first time demonstrate IgA deposition at that site.