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High prevalence of hepatitis C virus antibody and RNA in patients with oral cancer
Author(s) -
Nagao Yumiko,
Sata Michio,
Tanikawa Kyuichi,
Itoh Kyogo,
Kameyama Tadamitsu
Publication year - 1995
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1995.tb01199.x
Subject(s) - medicine , cancer , hepatitis c virus , saliva , gastroenterology , stomach cancer , antibody , etiology , liver cancer , hepatitis c , hepatitis , virus , immunology
We have investigated the correlation between the prevalence of hepatitis C virus (HCV), which is detectable in saliva, and oral cancer and other digestive tract cancers in the Northern Kyushu region of Japan. Anti‐HCV antibodies were detected in sera from 24 of the 100 patients with oral cancer (24%, p<0.05 vs the control group, p<0.01 vs the stomach cancer group), in 11 of 104 patients with non‐malignant diseases receiving dental treatment (the control group, 10.6%), and in 12 of 113 patients with stomach cancer (10.6%). HCV‐RNA was detected in sera from 17 of 100 oral cancer patients (17%, p<0.05 vs the control group) and 4 of 104 patients of the control group (3.9%). These results indicate a high prevalence of HCV infection in oral cancer patients, which warrants a systematic study of etiological associations between oral cancer and HCV.