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Integrin receptors and their relationship to cellular proliferation and differentiation of oral squamous cell carcinoma. A quantitative immunohistochemical study
Author(s) -
Kosmehl H.,
Berndt A.,
Katenkamp D.,
Hyckel P.,
Stiller K.J.,
Gabler U.,
Langbein L.,
Reh T.
Publication year - 1995
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1995.tb01197.x
Subject(s) - laminin , integrin , fibronectin , immunostaining , biology , extracellular matrix , pathology , epidermoid carcinoma , basement membrane , receptor , epithelium , immunohistochemistry , microbiology and biotechnology , cancer research , carcinoma , immunology , medicine , biochemistry
The expression of extracellular matrix (ECM) proteins (fibronectin, laminin, collagen IV) and ECM receptors of integrin type (α 2 β 1 , collagen receptor; α 6 chain of the fibronectin receptor; α 6 chain of the laminin receptor) were examined in normal oral squamous epithelium and in invasive areas of oral squamous cell carcinomas with various differentiation and proliferation activities (Ki‐67 antigen labelling), evaluating the presence, quantity (using an image analysis system) and distribution of the integrin subunits. In the mucosa, there was uniform immunostaining for α 2 β 1 and α 6 concentrated at the cell membrane in the basal/supra basal cell zone, whereas, α 5 showed a discontinuous staining of the basal cell‐basement membrane interface. α 2 and α 6 could be visualized in all carcinomas α 5 showed low expression preferentally in less differentiated carcinomas. In contrast to normal mucosa, there was an increase in α 6 staining in well‐differentiated carcinomas. Dedifferentiation of oral carcinomas was accompanied by an increase in cellular proliferation and with a decrease in α 2 β 1 and α 6 staining. This reduction of α 6 staining was shown to be statistically significant, suggesting that this integrin may be a valuable grading parameter for oral squamous cell carcinoma.