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Elevated ras p21 expression in oral premalignant lesions and squamous cell carcinomas in Taiwan
Author(s) -
Kuo M. Y. P.,
Chang H. H.,
Hahn L. J.,
Wang J. T.,
Chiang C. P.
Publication year - 1995
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1995.tb01178.x
Subject(s) - hyperkeratosis , epithelial dysplasia , pathology , medicine , dysplasia , immunostaining , immunohistochemistry , immunoperoxidase , oral mucosa , carcinoma , staining , dyskeratosis , antibody , monoclonal antibody , immunology
Expression of ras p21 oncoproteins was examined in histological sections of oral squamous cell carcinoma (SCC), epithelial dysplasia, epithelial hyperkeratosis and normal oral mucosa using antibodies to ras p21 with an immunoperoxidase technique. Ras p21‐positive staining was found in 47 of 51 (92.2%) cases of oral SCC, 4 of 4 (100%) cases of epithelial dysplasia, 7 of 7 (100%) cases of epithelial hyperkeratosis, and 1 of 6 (16.7%) cases of normal oral mucosa. The positive staining rate of ras p21 in oral SCC, epithelial dysplasia or epithelial hyperkeratosis was significantly higher than that in normal oral mucosa (P<0.05). No correlation was found between ras p21 expression and patient age, tumour location, tumour size, clinical staging or histological differentiation of SCC. However, a significant positive correlation was found between ras p21 expression and patients' sex (P<0.05) or regional lymph node status (P<0.05). A significant positive correlation was also discovered between ras p21 expression and patients' smoking habits (P<0.01), as well as daily or total betel quid (BQ) consumption (P<0.05). Of the 47 immunostain‐positive SCC patients, specimens from 6 patients were also obtained after chemotherapy, when ras p21 expression was found to be reduced. These results indicate that ras p21 over expression may play an important role in the initiation and progression of oral SCCs in patients who are smokers and BQ chewers.