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Osteolytic processes in human radicular cysts: morphological and biochemical results
Author(s) -
Formigli Lucia,
Orlandini Sandra Zecchi,
Tonelli Paolo,
Giannelli Marco,
Martini Monica,
Brandi Maria Luisa,
Bergamini Maurizio,
Orlandini Giovanni E.
Publication year - 1995
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1995.tb01170.x
Subject(s) - radicular cyst , bone resorption , pathology , resorption , acid phosphatase , capsule , connective tissue , multinucleate , giant cell , cyst , ultrastructure , osteoclast , anatomy , tartrate resistant acid phosphatase , prostaglandin e2 , chemistry , biology , medicine , biochemistry , botany , in vitro , enzyme
In an attempt to verify the nature of bone resorption processes on the bone surrounding radicular cysts, fragments of cysts with the adjacent bone tissue were studied by morphological, cytochemical and ultrastructural methods. Cyst fluid was analysed for its content of cytokines with osteolytic activity. The cyst wall exhibited several connective tissue extensions which penetrated the adjacent bone. Numerous multinucleated tartrate‐resistant acid phosphatase (TRAP)‐positive cells were seen at the tip of the intraosseous extensions of the cyst capsule and in direct contact with the bone tissue. Typical resorption lacunae were identified on the bone surface by scanning electron microscopy. Moreover, mononuclear TRAP‐positive cells were seen within the cyst capsule. High levels of prostaglan‐din E2 (PGE2) and interleukin‐6 (IL‐6) were detected in the cyst fluids. In conclusion, active bone resorption may contribute significantly to the growth of these lesions within the jaws.