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Experimental odontomas in osteopetrotic op/op rats
Author(s) -
Philippart C.,
Arys A.,
Dourov N.
Publication year - 1994
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1994.tb01113.x
Subject(s) - osteopetrosis , molar , pathology , tooth eruption , histology , medicine , resorption , bone resorption , odontogenic tumor , anatomy , dentistry , odontogenic
Osteopetrosis is an autosomal recessive disease in several mammalian species. Osteopetrotic op/op rats sutler from complete failure of tooth eruption related to reduced bone resorption. In our earlier studies, op/op rats grafted with bone marrow cells 3 days after birth were cured of the disease and their molar eruption was restored. However, the incisors failed to erupt and their proliferating ends were distorted, forming odontomas. The purpose of the present investigation was to study the odontogenic tissues in the odontomas, using the correlated techniques of radiography and microradiography of undecalcified material, together with histology of decalcified material and scanning electron microscopy.