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Comparison of a lesion‐inducing isolate and a non‐lesional isolate of Candida albicans in an immunosuppressed rat model of oral candidiasis
Author(s) -
Allen Carl M.,
Saffer Aron,
Meister Richard K.,
Beck Frank M.,
Bradway Steven
Publication year - 1994
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1994.tb01101.x
Subject(s) - candida albicans , lesion , corpus albicans , biology , tongue , microbiology and biotechnology , mycosis , pathology , inoculation , immunology , medicine
Two distinct strain‐related patterns of organism‐host interaction on dorsal tongue of immunocompetent rats have been identified for Candida albicans : some isolates induce mucosal lesions, while other isolates penetrate the keratin layer hut do not produce a lesion. This study examined the behavior of each of the two types of isolates in a cyclosporin‐immunosuppressed rat model. Groups B (normal) and D (cyclosporin) were orally inoculated with a lesion‐inducing isolate of C. albicans. while a non‐lesional isolate was given to Groups A (normal) and C (cyclosporin). A typical dorsal tongue lesion developed in 4/18 rats in Group B and in 13/16 in Group D ( p = 0.00267). No significant difference in infection rate between the normal and cyclosporin‐treated animals was seen for the non‐lesional isolate. The lack of a host inflammatory response associated with the non‐lesional isolate may represent an ecologic advantage for the organism.