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Influence of inductive chemoradiotherapy on salivary polymorphonuclear leukocyte (SPMN) functions in oral cancer
Author(s) -
Ueta Eisaku,
Osaki Tokio,
Yoneda Kazunori,
Yamamoto Tetsuya,
Umazume Makoto
Publication year - 1994
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1994.tb00088.x
Subject(s) - phagocytosis , neutrophile , medicine , chemotaxis , superoxide , cancer , granulocyte , basal cell , gastroenterology , endocrinology , immunology , inflammation , chemistry , receptor , biochemistry , enzyme
Salivary polymorphonuclear leukocyte (SPMN) functions were examined in 1 8 patients with oral squamous cell carcinoma and in 2 0 healthy individuals. SPMN obtained from patients before therapy exhibited significantly less FMLP‐stimulated chemotactic activity (132.4 ± 17.5 cells/0.26 mm2) than that in SPMN from controls (177.1 ± 11.6 cells/0.26 mm2), although no difference in phagocytosis was observed. When stimulated with PMA or FMLP, control SPMN generated superoxide (CV) at levels of 50.3 ± 10.5 pmol/min/1 0 4 cells and 8 8.4 ± 1 5.4 pmol, respectively, while SPMN from untreated patients generated significantly reduced O, in the presence of PMA or FMLP (2 4.3 + 3.5 pmol and 5 9.5 ± 9.8 pmol, respectively). Only slightly lower chemiluminescence was observed in SPMN from untreated patients however, compared to controls, values being 6 8.0 ± 1 8.9vs 81.3 ± 14.9 peak mV by PMA and 62.4 ± 3.7 vs 64.4 ± 12.9 peak mV by FMLP. Compared to Candida killing in control subjects (2 4.9 ± 3.1 %), SPMN from patients before treatment exhibited significantly reduced activity (1 8.7 ± 4.9 %). Further suppression of the SPMN functions examined was observed after chemoradio‐therapy. Suppressed SPMN function in cancer patients, especially that associated with chemoradiolhcrapy, may therefore play a part in oral candidiasis.