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High incidence of H‐ras oncogene mutations in squamous cell carcinoma of lip vermilion
Author(s) -
Milašin J.,
Pujić N.,
Dedović N.,
Nikolić Ž.,
Petrović V.,
Dimitrijević B.
Publication year - 1994
Publication title -
journal of oral pathology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.887
H-Index - 83
eISSN - 1600-0714
pISSN - 0904-2512
DOI - 10.1111/j.1600-0714.1994.tb00065.x
Subject(s) - vermilion , basal cell , oncogene , biology , oligonucleotide , mutation , dna , gene , cancer research , cell , carcinoma , microbiology and biotechnology , pathology , genetics , medicine , chemistry , cell cycle , organic chemistry
Nine specimens of well‐differentiated squamous cell carcinoma of the lip vermilion have been analyzed for the pressence of H‐ras oncogene mutations, using the technique of hybridization with synthetic oligonucleotide probes on in vitro amplified tumour DNA. Five specimens harbored mutations: four in codon 12 and one in codon 13. This high incidence (55%) of mutated H‐ras genes suggests that their activation may play an important role in lip tumour development and may be connected to the exposure to chemical and/or physical carcinogens.